Melatonin, Lipofuscin, and Age-Related Neurodegeneration: Reflections on Light at Night

[Source: Litvinenko, G. I.; Gritsyk, O. B.; Mel’nikova, E. V.; Avrorov, P. A.; Tenditnik, M. V.; Shurlygina, A. V.; Trufakin, V. A. Changes in the Interaction of the Pineal Gland and Immune System Organs in Rats in Response to Administration of Melatonin in Conditions of an Altered Light Regime. Neurosci. Behav. Physiol. 2016, 46, 882–887]

Today’s story on melatonin is inspired by a recent peer-reviewed study that showed the important role played by a common autofluorescent pigment called lipofuscin in age-related neurodegeneration and traumatic brain injury in animal models [Ritzel et al. 2023].