#Lohcurve. When one is ahead of the curve, it takes time for others to catch up.
18 months after my peer-reviewed paper on SARS-CoV-2 association with CD147 signaling was published (Loh, D. 2020. The potential of melatonin in the prevention and attenuation of oxidative hemolysis and myocardial injury from cd147 SARS-CoV-2 spike protein receptor binding. Melatonin Research. 3, 3 (Jun. 2020), 380-416. DOI:https://doi.org/https://doi.org/10.32794/mr11250069), there are there are now 14 citations of my paper per Google Scholar. Why would others cite my research if it is not scientifically sound?
Is the CD147 signaling pathway truly relevant during SARS-CoV-2 viral infection and replication?
If you search for “CD147” and “SARS-CoV-2” on the PubMed database, you will find 103 results as of today (2/15/2022). Some of the more informative discussions on SARS-CoV-2 and CD147 can be found in the following articles which I must emphasize, is not a comprehensive list and I apologize to researchers, scientists, and authors whose work are not included below:
1. Behl, T.; Kaur, I.; Aleya, L.; Sehgal, A.; Singh, S.; Sharma, N.; Bhatia, S.; Al-Harrasi, A.; Bungau, S. CD147-Spike Protein Interaction in COVID-19: Get the Ball Rolling with a Novel Receptor and Therapeutic Target. Sci. Total Environ. 2021, 152072. https://doi.org/10.1016/j.scitotenv.2021.152072.
2. Avolio, E.; Carrabba, M.; Milligan, R.; Kavanagh Williamson, M.; Beltrami, A.; Gupta, K.; Elvers, K. T.; Gamez, M.; Foster, R.; Gillespie, K.; Hamilton, F.; Arnold, D.; Berger, I.; Davidson, A.; Hill, D. J.; Caputo, M.; Madeddu, P. The SARS-CoV-2 Spike Protein Disrupts Human Cardiac Pericytes Function through CD147-Receptor-Mediated Signalling: A Potential Non-Infective Mechanism of COVID-19 Microvascular Disease. Clin. Sci. 2021. https://doi.org/10.1042/CS20210735.
3. Avolio, E.; Carrabba, M.; Milligan, R.; Williamson, M. K.; Beltrami, A. P.; Gupta, K.; Elvers, K. T.; Gamez, M.; Foster, R.; Gillespie, K.; Hamilton, F.; Arnold, D.; Berger, I.; Caputo, M.; Davidson, A. D.; Hill, D.; Madeddu, P. The SARS-CoV-2 Spike Protein Disrupts Human Cardiac Pericytes Function through CD147-Receptor-Mediated Signalling: A Potential Non-Infective Mechanism of COVID-19 Microvascular Disease. bioRxiv, 2021, 2020.12.21.423721. https://doi.org/10.1101/2020.12.21.423721.
4. Fenizia, C.; Galbiati, S.; Vanetti, C.; Vago, R.; Clerici, M.; Tacchetti, C.; Daniele, T. SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2. Cells 2021, 10 (6). https://doi.org/10.3390/cells10061434.
5. Staffler, G.; Szekeres, A.; Schütz, G. J.; Säemann, M. D.; Prager, E.; Zeyda, M.; Drbal, K.; Zlabinger, G. J.; Stulnig, T. M.; Stockinger, H. Selective Inhibition of T Cell Activation via CD147 through Novel Modulation of Lipid Rafts. J. Immunol. 2003, 171 (4), 1707–1714. https://doi.org/10.4049/jimmunol.171.4.1707.
6. Rapozzi, V.; Juarranz, A.; Habib, A.; Ihan, A.; Strgar, R. Is Haem the Real Target of COVID-19? Photodiagnosis Photodyn. Ther. 2021, 102381. https://doi.org/10.1016/j.pdpdt.2021.102381.
Almost all the relevant mechanisms associated with CD147 in COVID19 infections that were discussed in my June 2020 paper are now fully explored by other scientists and researchers as evidenced by the impressive list above. My lack of formal training in science and my background in music certainly did not prevent me from presenting formidable research that is ahead of the curve.
